Abstract #1237

Longitudinal assessment of changes in the BBB water permeability in a mouse model of Huntington's Disease using multi-TE ASL MRI

Joëlle van Rijswijk^1,2, Johan Van Audekerke^1,2, Ignace Van Spilbeeck^1,2, Yolanda Ohene^3,4,5, Jack Wells⁶, Tamara Vasilkovska^1,2, Haiying Tang⁷, Roger Cachope⁷, Dorian Pustina⁷, Mohit Adhikari^1,2, Daniele Bertoglio^1,2, and Marleen Verhoye^1,2

¹Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium, ²µNeuro Research Center of Excellence, University of Antwerp, Antwerp, Belgium, ³Division of Psychology, Communication and Human Neuroscience, University of Manchester, Manchester, United Kingdom, ⁴Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, United Kingdom, ⁵Wissenschaftskolleg zu Berlin, Berlin, Germany, ⁶UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ⁷CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Princeton, NJ, United States

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration, Huntington's Disease

Motivation: Huntington’s disease (HD) lacks disease-modifying treatments. Investigating blood-brain barrier (BBB) water permeability may reveal early biomarkers of disease progression.

Goal(s): The study aims to assess BBB water permeability in the zQ175DN HD mouse model by analyzing longitudinal changes in water exchange time using multi-TE ASL MRI.

Approach: Analysis was performed in control and HD mice at 3, 6, and 9 months of age, focusing on water exchange time in striatum and cortical regions.

Results: Reduced water exchange time was observed in the somatosensory and cingulate cortex in HD mice, suggesting increased BBB permeability at 9 months of age.

Impact: This study indicates that using the non-invasive multi-TE ASL MRI technique, alterations in water exchange time can be detected in the zQ175DN mouse model of Huntington’s Disease at 9 months of age.

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