Abstract #1238

Influence of Infusion Location, Rate, and Anesthesia on CSF Tracer Dynamics in Mouse Brain

Yuran Zhu¹, Junqing Zhu², Chenxin Ni¹, Anbang Chen³, Longshun Li¹, Yue Gao¹, Andrew J. Shoffstall¹, and Xin Yu^1,2,4

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ³Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Contrast Agent

Motivation: To comprehensively understand how tracer infusion and anesthesia impact tracer transport in cerebrospinal fluid (CSF).

Goal(s): To compare differences in transport dynamics and distribution patterns of Gd-DTPA under different infusion conditions and anesthetics.

Approach: The kinetics and distribution of Gd-DPTA were assessed by DCE-MRI following its infusion at different intra cisterna-magna (ICM) infusion rates (1 μL/min for 10 min versus 0.33 μL/min for 30 min), under different anesthetics (isoflurane versus K/X), and into different locations (ICM versus intraventricular, ICV).

Results: While anesthesia is crucial, infusion location and infusion rate are also key factors impacting transport pathways and kinetics.

Impact: This study investigated the impact of infusion location, rate, and anesthesia on Gd-DTPA transport dynamics and distribution patterns across the whole brain, providing insights into CSF transport pathways and regulation in the brain.

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