Abstract #1239

Imaging the Ischemic Penumbra with IVIM

Mira Liu^1,2, Niloufar Saadat³, Steven Roth⁴, Mohammed Salman Shazeeb⁵, Mihai Giurcanu⁶, Timothy Carroll¹, and Gregory Christoforidis³

¹Medical Physics, University of Chicago, Chicago, IL, United States, ²Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Interventional Radiology, University of Chicago, Chicago, IL, United States, ⁴Anesthesiology, University of Illinois Chicago, Chicago, IL, United States, ⁵Radiology, UMass Chan Medical School, Worcester, MA, United States, ⁶Statistics, University of Chicago, Chicago, IL, United States

Synopsis

Keywords: Stroke, IVIM

Motivation: Non-contrast accurate simultaneous perfusion diffusion could improve study of ischemic penumbra development in pre-clinical stroke research of novel therapeutics.

Goal(s): Examine intravoxel incoherent motion (IVIM) perfusion and diffusion compared to local-AIF DSC in acute stroke with varying compensatory collateral supply

Approach: Pre-clinical animal model of middle cerebral artery occlusion with IVIM, T1-bookend dynamic susceptibility (DSC), and diffusion tensor (DTI) MRI.

Results: IVIM showed sensitivity to local compensatory collateral flow, transport time, and perfusion-diffusion mismatch in acute ischemic stroke penumbra. IVIM agreed with Local-AIF DSC qCBF and predicted final infarct volume, supporting capture of “local perfusion” with compensatory collateral flow.

Impact: As IVIM is a non-contrast method that includes compensatory collateral supply, it poses itself to be a viable candidate for longitudinal measurement of simultaneous perfusion and diffusion in pre-clinical stroke research.

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