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Abstract #1243

Hubness of Paraventricular Thalamic Nucleus Predicts Thalamocortical Connectivity Changes Driven by Locus Coeruleus Activity

LiMing Hsu1, Chengbo Meng2, Guohong Cui2, Patricia Jensen3, and Yen-Yu Ian Shih4
1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2In Vivo Neurobiology Group, National Institute of Environmental Health and Sciences, Raligh, NC, United States, 3Developmental Neurobiology Group, National Institute of Environmental Health and Sciences, Raligh, NC, United States, 4Department of Neurology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Neurotransmission, fMRI (resting state), small animals

Motivation: The medial prefrontal cortex (mPFC) is modulated by noradrenergic neurons from the locus coeruleus (LC) noradrenergic neurons and has reciprocal connection with thalamus, forming a circuit essential for goal-directed behavior.

Goal(s): To understand how the paraventricular thalamic nucleus (PVT) integrates LC-NE signaling to modulate thalamocortical connectivity and its role in behaviors.

Approach: This study used chemogenetics and fMRI to explore the thalamus's regulatory role on LC-driven connectivity changes.

Results: Findings highlight the paraventricular thalamic nucleus (PVT) as a key predictor of LC-induced alterations in thalamocortical connectivity.

Impact: This work reveals how the hubness of specific thalamic nuclei modulates thalamocortical circuits, offering insights into individual variability in LC-related behavior and potential implications for treating neuropsychiatric disorders.

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