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Abstract #1244

Aging Effect on Cerebral Microvascular Volumetric Pulsatility Revealed by High-Resolution 4D CBV and ASL MRI at 7T

Fanhua Guo1, Chenyang Zhao1, Qinyang Shou1, Ning Jin2, Kay Jann1, Xingfeng Shao1, and Danny JJ Wang1
1University of Southern California, Los Angeles, CA, United States, 2Siemens Healthcare USA, Malvern, PA, United States

Synopsis

Keywords: Vascular/Vessel Wall, Aging, arterial pulsation, VASO, glymphatic system

Motivation: Microvascular pulsation is crucial for glymphatic system and may influence neuronal activity. It remains challenging to measure microvascular pulsatility using noninvasive imaging technology.

Goal(s): This study aims to develop a new method to quantify cerebral microvascular volumetric pulsatility index (mvPI) and investigate its changes with age.

Approach: Using 7T high-resolution 4D-VASO and ASL MRI, we measured mvPI across cortical-laminae and white matter.

Results: mvPI was highest in CSF at the cortical surface, which decreased towards the cortical layers as well as in larger arteries. In the deep WM, a significantly increased mvPI was observed in older compared to younger.

Impact: Our method offers the first in vivo measurement of microvascular volumetric pulsatility in human brain which has implications for cerebral microvascular health and its relationship research with glymphatic system, aging and neurodegenerative diseases.

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