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Abstract #1245

Cerebrovascular Reactivity to CO2 Differences in Aging Adults Identified by a Coherence Weighted Frequency-Domain Analysis of BOLD MRI

Bethany L Sussman1, Hannah E Wiseman1, Sudarshan Ranganathan1,2, K Austin Davis3, Botian Xu2, Raul Vintimilla3, John C Wood2, Caroline A Rickards3, Niema M Pahlevan4,5, Kevin S King6, and Matthew T Borzage1,7,8
1Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Division of Cardiology, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 3Department of Physiology & Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States, 4Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, United States, 5Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6Department of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, United States, 7Alfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States, 8Department of Regulatory and Quality Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Aging, Aging, Cerebrovascular Reactivity, BOLD, neurovascular

Motivation: Maps of cerebrovascular reactivity (CVR) to CO2 facilitates detection of cerebrovascular disease and assess stroke risk, but the cumbersome acquisition and analysis of synchronized imaging and physiological data limits their use in large studies.

Goal(s): Demonstrate a Blood Oxygen-Level Dependent (BOLD) and end-tidal CO2 (ETCO2) acquisition and analytical approach suitable for mapping CVR in a large study.

Approach: We acquired and analyzed BOLD and ETCO2 changes during breathing tasks in 53 aging adults and calculated BOLD-CVR to CO2 with a frequency-domain coherence-weighting.

Results: During breathing tasks, female versus male participants showed an age-dependent increase in BOLD-CVR to CO2.

Impact: More accessible BOLD and ETCO2 acquisition and analysis techniques using mild breathing tasks can lead to more widespread use of BOLD-CVR to CO2 in a variety of populations and might facilitate more widespread characterization of cerebrovascular health and risk factors.

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