Abstract #1258

Development of GRASE Pulse Sequence with larger field of view for Mesoscale functional MRI on the Next Generation (NexGen) 7T scanner

Alexander Beckett^1,2, Suhyung Park³, Suvi Häkkinen¹, Erica Walker^1,2, An Vu^4,5, and David A Feinberg^1,2

¹Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, ²Advanced MRI Technologies, Sebastopol, CA, United States, ³Department of Intelligent Electronics and Computer Engineering, Chonnam National University, Gwangju, Korea, Republic of, ⁴Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ⁵San Francisco Veteran Affairs Health Care System, San Francisco, CA, United States

Synopsis

Keywords: Image Reconstruction, fMRI Acquisition

Motivation: Mesoscale fMRI using GRASE has been shown to be less susceptible to pial bias, but is hampered by small coverage and lower SNR then GE BOLD.

Goal(s): Acceleration methods incorporating random sampling have been shown to increase coverage and boost SNR, but are still somewhat limited by hardware.

Approach: Combining accelerated GRASE with random sampling with the improved hardware of the NexGen 7T allows FOV to be expanded and resolution to be increased.

Results: High-resolution fMRI in visual and sensorimotor cortices demonstrates that accelerated GRASE can be used for mesoscale functional imaging.

Impact: The advanced hardware of the NexGen 7T combined with accelerated 3D GRASE incorporating random sampling allows for increases in coverage and resolution to enable mesoscale imaging. GRASE images show decreased pial vein and brain surface layer bias than GE-EPI

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.