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Abstract #1259

Blood-nulling versus tissue-suppression: Enhancing integrated VASO and perfusion (VAPER) contrast for laminar fMRI

Yuhui Chai1, Linqing Li2, Rüdiger Stirnberg3, Laurentius Huber2, Tony Stöcker3,4, Peter Bandettini2, and Bradley Sutton1
1Beckman Institute, UIUC, Urbana, IL, United States, 2NIMH, NIH, Bethesda, MD, United States, 3DZNE, Bonn, Germany, 4University of Bonn, Bonn, Germany

Synopsis

Keywords: Mesoscale: columns and layers, fMRI (task based)

Motivation: CBV and CBF based layer fMRI sequence methods suffer from relatively low sensitivity.

Goal(s): We aim to induce addtional CBV sensitivity through MT to boost overall VAPER-fMRI sensitivity.

Approach: We explored an innovative application of MT to induce a tissue-suppression-based VASO effect and integrate it with the VAPER technique.

Results: Both theoretical and experimental evaluation demonstrated approximately 30% enhancement in VAPER sensitivity with MT application compared to the original VAPER without MT.

Impact: We proposed an innovative MT-enhanced VAPER imaging sequence for layer fMRI that enhances sensitivity by 30% compared to traditional VAPER without MT, while maintaining superior laminar specificity without increasing acquisition time.

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