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Abstract #1274

Open EPTI: pluggable, distortion-free continuous readout developed on vendor-neutral Pulseq for versatile multi-contrast MR imaging

Jian Wu1,2, Timothy G. Reese1,2, Shohei Fujita1,2, Berkin Bilgic1,2, Lawrence L. Wald1,2,3, Zijing Dong1,2, and Fuyixue Wang1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Data Acquisition, Acquisition Methods, Pulse Sequence Design

Motivation: EPTI provides an efficient, distortion-free readout, offering spatiotemporal resolutions comparable to EPI while addressing its limitations, which can be beneficial for various multi-contrast applications.

Goal(s): In line with open-science and acquisition harmonization efforts, we aim to develop EPTI in open-source, vendor-neutral sequence/reconstruction platforms.

Approach: We developed both multi-shot and single-shot EPTI in Pulseq with streamlined reconstruction in Gadgetron/BART, and demonstrated Pulseq-EPTI readout in three contrast acquisitions: i) quantitative MRI through GE-SE EPTI; ii) fMRI using GE-EPTI; iii) metabolic CEST imaging using CEST-prepared EPTI.

Results: Pulseq-EPTI provides a pluggable, distortion-free readout module, enabling efficient qMRI, fMRI, and CEST imaging.

Impact: We developed EPTI into vendor-neutral sequence/reconstruction frameworks, providing a pluggable, distortion-free readout for multi-contrast MR imaging. As proof-of-concept, we demonstrated Pulseq-EPTI readout in three contrast acquisitions tailored to three different applications, including quantitative MRI, fMRI, and CEST imaging.

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Keywords