Abstract #1317

Optimization and application of MP2RAGE sequence for T1-based thermometry in the fat layer of the human calve

Koen M. Custers^1,2, Mathijs W.I. Kikken^1,2,3, Ettore F. Meliadò^2,3,4, Cornelis A.T. van den Berg^2,3, Josien P.J. Pluim^1,5,6, and Alexander J.E. Raaijmakers^1,2,3

¹Biomedical Engineering, Medical Imaging Analysis, Eindhoven University of Technology, Eindhoven, Netherlands, ²Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ³Computational Imaging Group for MR diagnostics & therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Tesla Dynamic Coils BV, Zaltbommel, Netherlands, ⁵Eindhoven Artificial Intelligence Systems Institute, Eindhoven University of Technology, Eindhoven, Netherlands, ⁶Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Safety, Safety, Thermometry, T1-based

Motivation: MR Thermometry is highly valuable for RF safety research. However, the most common method (PRFS) cannot measure temperature in fat.

Goal(s): Establish a method for T1-based thermometry in fat with high sensitivity to measure sub-degree temperature rise.

Approach: Utilize the MP2RAGE sequence to measure temperature-induced T1 changes and optimize imaging parameters through Bloch simulations. Test the method with phantom experiments and in-vivo measurements.

Results: The proposed T1-based thermometry method demonstrates sufficient sensitivity to measure RF-induced temperature rise in muscle and fatty tissues while abiding SAR limits of regular MRI sequences.

Impact: We present a highly sensitive T1-based thermometry method applicable in fatty tissues for RF safety research. MRT in fat will be valuable to improve verification by fiber-optic probes on the skin and -using intrinsic reference- assessment of fat susceptibility change.

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