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Abstract #1346

The default mode network is causally involved in memory retrieval and network integration plays a key role in this process

Zengmin Li1, Dilsher Athwal2, and Kai-Hsiang Chuang1
1School of Biomedical Sciences, The University of Queensland, Brisbane, Australia, 2Queensland Brain Institute, The University of Queensland, Brisbane, Australia

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, Default Mode Network, Memory

Motivation: Network integration is crucial for learning and memory, but whether the integration of default mode network (DMN) supports memory processes remains unclear.

Goal(s): This study aims to assess if modulating DMN integration causally affects memory precess.

Approach: In C57 mice, we chemogenetically suppressed the DMN hub, the dorsal anterior cingulate cortex (dACC), and analyzed DMN architecture using resting-state fMRI, alongside memory behavior tests.

Results: Inhibition of dACC disrupted DMN integration and impaired memory recall. The altered DMN integration correlated with behavioral deficits, suggesting its critical role in memory process.

Impact: Our results show that DMN plays a causal role in memory processes, emphasizing the importance of network integration for memory. These findings enhance our understanding of DMN's involvement in higher-order cognition and offer potential measurement methods for various brain disorders.

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Keywords