Keywords: Functional Connectivity, fMRI (resting state)
Motivation: Resting-state functional connectivity is believed to reflect polysynaptic connectivity, but whether spontaneous neural interactions involve polysynaptic connectivity remains unclear.
Goal(s): This study investigates the role of polysynaptic connectivity in propagating spontaneous neural activity.
Approach: We mapped evoked and spontaneous neural interactions using mouse fMRI with optogenetic activation or silencing of neural activity and compared them with polysynaptic structural connectivity.
Results: Spontaneous activity propagated through polysynaptic pathways, while evoked activity was confined to monosynaptic connectivity. This suggests that polysynaptic connectivity is crucial in shaping spontaneous neural interactions underlying functional connectivity.
Impact: This study aimed to elucidate the relationship between resting-state functional connectivity and causal neural interactions assessed by optogenetic fMRI, with a specific focus on the role of polysynaptic structural pathways.
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