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Abstract #1350

Optogenetic-silencing mouse fMRI reveals spontaneous neural activity propagating through polysynaptic structural connectivity

Hyun Seok Moon1,2 and Seong-Gi Kim1,2
1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: Functional Connectivity, fMRI (resting state)

Motivation: Resting-state functional connectivity is believed to reflect polysynaptic connectivity, but whether spontaneous neural interactions involve polysynaptic connectivity remains unclear.

Goal(s): This study investigates the role of polysynaptic connectivity in propagating spontaneous neural activity.

Approach: We mapped evoked and spontaneous neural interactions using mouse fMRI with optogenetic activation or silencing of neural activity and compared them with polysynaptic structural connectivity.

Results: Spontaneous activity propagated through polysynaptic pathways, while evoked activity was confined to monosynaptic connectivity. This suggests that polysynaptic connectivity is crucial in shaping spontaneous neural interactions underlying functional connectivity.

Impact: This study aimed to elucidate the relationship between resting-state functional connectivity and causal neural interactions assessed by optogenetic fMRI, with a specific focus on the role of polysynaptic structural pathways.

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