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Abstract #1361

Fluid-suppressed APTw and NOEw MRI as Protein-Related Biomarkers for Differentiating IDH Status in Gliomas

Stefano Casagranda1, Capucine Cadin2, Ottavia Dipasquale1, Lucia Nichelli2,3, Bertrand Mathon2,3, Marc Sanson2,3, Moritz Zaiss4, Stéphane Lehéricy2,3, and Francesca Branzoli2
1Department of R&D Advanced Applications, Olea Medical, La Ciotat, France, 2Paris Brain Institute - ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France, 3Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière-Charles-Foix, Paris, France, 4Department of Neuroradiology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE, IDH status

Motivation: Noninvasive identification of IDH status in gliomas is crucial for clinical management but remains challenging.

Goal(s): To evaluate APT-weighted and NOE-weighted MRI as biomarkers for distinguishing gliomas with IDH mutations.

Approach: Application of APT-weighted and NOE-weighted MRI techniques to analyze in vivo protein-related markers in 34 glioma patients on a 3T MR scanner.

Results: Significant differences in fluid-suppressed APT-weighted signals allowed for effective differentiation between gliomas with and without IDH mutations.

Impact: The results demonstrated the potential of fluid-suppressed APT-weighted MRI as a noninvasive method to improve diagnostic precision in predicting IDH status and optimize clinical management of gliomas.

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