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Abstract #1421

Ex vivo diffusion MRI protocol optimization on the Connectome 2.0 scanner for reconstructing cortico-subcortical projections

Chiara Maffei1, Ting Gong1, Dongsuk Sung1, Gabriel Ramos-Llorden1, Alina Scholz2, Mirsad Mahmutovic2, Boris Keil2, Susie Y. Huang1, Angela M. Noecker3, Cameron C. McIntyre3, and Anastasia Yendiki1
1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Mittelhessen University of Applied Sciences, Giessen, Germany, 3Duke University, Durham, NC, United States

Synopsis

Keywords: Tractography, Ex-Vivo Applications

Motivation: As part of the BRAIN Initiative Connectivity across Scales (CONNECTS) program, we are planning to image ex vivo human brains with mesoscopic diffusion MRI (dMRI) and downstream correlative microscopy.

Goal(s): The goal of this study is to optimize the dMRI protocol, with an emphasis on reconstructing pathways relevant to deep-brain stimulation.

Approach: We perform the first study evaluating ex vivo dMRI protocols on the Connectome 2.0 scanner, by comparing dMRI tractography against reference tracts from an atlas annotated by neuroanatomic experts.

Results: Our preliminary evaluation suggests a protocol for satisfactory reconstruction of the tracts of interest at 0.55mm resolution.

Impact: We seek to establish a cutting-edge diffusion MRI protocol to collect data on ex vivo human brains, which will be accompanied by correlative microscopy and serve as a resource for the research community, to benefit both methodological and neuroanatomic studies.

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Keywords