Keywords: Structural Connectivity, Normal development, Brain Connectivity, Functional Connectivity, Multimodal
Motivation: Cortical morphology represents the fundamental structural architecture of the cerebral cortex. However, the lifespan growth patterns of morphology-based structural networks remain unknown.
Goal(s): Model the lifespan growth of the morphometric network and its associations with the functional connectome.
Approach: We aggregated a neuroimaging dataset of 33,937 healthy participants aged 0 to 80 from 141 sites, constructing individual morphometric and functional networks to map normative growth patterns.
Results: Lifespan structural network growth shows connectivity strength decreasing in sensory regions and increasing in paralimbic regions. Coupling increased from birth to early adolescence, followed by a decline. Network phenotype deviations in patients significantly predicted clinical scores.
Impact: Our results reveal the lifespan evolution of the morphology-based structural network and provide a normative reference for assessing individual variations in development, aging, and neuropsychiatric disorders.
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