Keywords: Structural Connectivity, Brain Connectivity, CEST, glutamate, molecular connectivity, molecular networks
Motivation: The study addresses the need for non-invasive mapping of glutamate networks in the brain, crucial for understanding glutamate's role in neurological disorders.
Goal(s): To demonstrate the feasibility of mapping glutamate networks in the mouse brain using CEST MRI.
Approach: CEST MRI was used to capture glutamate levels through GluCEST imaging. Two acquisition methods—dynamic time-series data and RF-varying Z-spectra—were employed, with independent component analysis and seed-based correlation to analyze glutamate connectivity.
Results: The study successfully mapped glutamate networks in the mouse brain, showing connectivity between regions such as the hippocampus and cortex, and validated CEST MRI's capability for molecular-level brain connectivity imaging.
Impact: This study shifts how glutamate's role in the brain is investigated, enabling targeted, non-invasive imaging of its networks. By establishing a method to map glutamate connectivity, it opens new avenues for studying region-specific alterations in neurological disorders.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords