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Abstract #1469

Mapping Glutamate Networks in the Mouse Brain Using CEST MRI

Yutong Liu1, Mariano Uberti1, Adarsha Bhattarai2, Chathumi Samaraweera2, Aditya N. Bade3, and Dongming Peng2
1Radiology, University of Nebraska Medical Center, Omaha, NE, United States, 2Electrical and Computer Engineering, University of Nebraska – Lincoln, Omaha, NE, United States, 3Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States

Synopsis

Keywords: Structural Connectivity, Brain Connectivity, CEST, glutamate, molecular connectivity, molecular networks

Motivation: The study addresses the need for non-invasive mapping of glutamate networks in the brain, crucial for understanding glutamate's role in neurological disorders.

Goal(s): To demonstrate the feasibility of mapping glutamate networks in the mouse brain using CEST MRI.

Approach: CEST MRI was used to capture glutamate levels through GluCEST imaging. Two acquisition methods—dynamic time-series data and RF-varying Z-spectra—were employed, with independent component analysis and seed-based correlation to analyze glutamate connectivity.

Results: The study successfully mapped glutamate networks in the mouse brain, showing connectivity between regions such as the hippocampus and cortex, and validated CEST MRI's capability for molecular-level brain connectivity imaging.

Impact: This study shifts how glutamate's role in the brain is investigated, enabling targeted, non-invasive imaging of its networks. By establishing a method to map glutamate connectivity, it opens new avenues for studying region-specific alterations in neurological disorders.

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