Meeting Banner
Abstract #1473

Altered effective connectivity in LGI-1 antibody encephalitis: a spectral dynamic causal modeling study

Ziyao Liu1, Wenlong Xu2, Dandan Zhang1, Jiaxiang Xin3, Jianping Qiao2, and Anning Li1
1Qilu Hospital of Shandong University, Jinan, China, 2Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, Institute of Data Science and Technology,School of Physics and Electronics,Shandong Normal University, Jinan, China, 3MR Research Collaboration Team,Siemens Healthineers Ltd, Shanghai, China

Synopsis

Keywords: Structural Connectivity, Brain Connectivity, LGI1,Autoimmune encephalitis

Motivation: Causal changes in effective connectivity within brain networks of patients with leucine-rich glioma inactivated 1 (LGI1) antibody encephalitis are poorly understood, limiting targeted interventions for symptom management.

Goal(s): To identify effective connectivity patterns among key brain regions in patients with anti-LGI1 and examine their correlation with symptom severity and cognitive function.

Approach: A spectral dynamic causal model analyzed connectivity in fMRI data of patients with anti-LGI1 encephalitis, comparing it with healthy controls.

Results: Our findings revealed distinct connectivity patterns in patients with anti-LGI1, with variations correlating to symptom severity and cognitive deficits, indicating specific causal relationships in brain networks.

Impact: This study enhances understanding of brain connectivity in anti-LGI1 encephalitis, potentially leading to new diagnostic biomarkers and targeted therapies. Improved insights into causal relationships may substantially enhance patient management and treatment outcomes in autoimmune encephalitis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords