Abstract #1485

Combined Diffusion Relaxometry: Phantom Validation and Ex Vivo Characterization of Alzheimer’s Disease Lesions

Andrea Jacobson¹, Amaya Murguia ², Scott D. Swanson³, Ulrich Scheven⁴, Jon-Fredrik Nielsen^1,3, Jeffery A. Fessler², and Navid Seraji-Bozorgzad⁵

¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ²Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States, ³Radiology, University of Michigan, Ann Arbor, MI, United States, ⁴Mechanical Engineering, University of Michigan, Ann Arbor, MI, United States, ⁵Neurology, University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: White Matter, Alzheimer's Disease, Combined Diffusion Relaxometry

Motivation: There is a need for better characterization of white matter lesions in Alzheimer’s disease and related disorders (ADRD) to distinguish between benign lesions and destructive lesions.

Goal(s): Evaluate the utility of diffusion-T₂ (D-T₂) 2-dimensional MR in characterizing white matter abnormalities in post-mortem ADRD samples.

Approach: We scanned a D-T₂ phantom (spin-echo D-T₂) and post-mortem ADRC brain samples (EPI D-T₂), then we computed their 2D spectras.

Results: We successfully validated our D-T₂ protocol with the phantom. D-T₂ spectra resolved tissue components of varying T₂ and diffusion values in normal and abnormal white matter, revealing more information than 1D diffusion tensor imaging ADC outcomes.

Impact: The D-T₂ phantom can serve as a standard for validating D-T₂ imaging protocols. Applying D-T₂ to assess ADRD lesions could allow for more disease-specific diagnostics with MRI.

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