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Abstract #1489

Visualization of in-vivo brainstem myeloarchitecture via χ-separation at 7T

Jiye Kim1, Chungseok Oh1, Ana-Maria Oros-Peusquens2, N. Jon Shah2, Chul-Ho Shon3, Huijin Song4, and Jongho Lee1
1Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Institute of Neuroscience and Medicine 4 (INM-4), Research Centre Juelich, Juelich, Germany, 3Departments of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea, Republic of, 4Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of

Synopsis

Keywords: White Matter, White Matter, chi-separation, brainstem, anatomy

Motivation: Brainstem regulates vital functions and connects the brain and spinal cord. Investigating its detailed structure and alteration, particularly in myelin-related areas, is important in understanding their functions and tracking neurodegenerative diseases.

Goal(s): We aim to generate high-resolution myelin-distribution maps using χ-separation and validate them with histology images.

Approach: High-resolution (<0.5 mm) χ-separation maps were generated utilizing the 7T χ-separation method along with modified resolution generalization method. The resulting diamagnetic susceptibility maps are compared with myelin-stained maps.

Results: We produced high-quality and high-resolution 𝜒-separation maps, closely aligning with myelin-stained images and capturing myelin-rich structures such as corticospinal fibers, transverse pontine fibers, and medial lemniscus.

Impact: This study demonstrates that 7T χ-separation can generate high-resolution (<0.5 mm) diamagnetic susceptibility (mostly myelin) maps of in-vivo brainstem, closely matching myelin histology. This may benefit detailed analysis of structure and myelin concentration changes in brainstem, relevant to neurodegenerative diseases.

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