Abstract #1499

Atherosclerosis severity in the internal carotid artery is associated with elevated white matter lesion burden in the supplied brain territories

Deniz Karakay^1,2, Haley Wiskoski³, Anna Peckham⁴, Juan Arias⁴, Dianne Patterson⁵, Karthik Rayasam², Raza Mushtaq⁶, Kevin Johnson², Theodore Trouard³, Maria Altbach^2,3, Ali Bilgin^1,2,3, and Craig Weinkauf⁴

¹Department of Electrical & Computer Engineering, University of Arizona, Tucson, AZ, United States, ²Department of Medical Imaging, University of Arizona, Tucson, AZ, United States, ³Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ⁴Department of Surgery, University of Arizona, Tucson, AZ, United States, ⁵Translational Bioimaging Resource, University of Arizona, Tucson, AZ, United States, ⁶Department of Neuroradiology, Barrow Neurological Institute, Phoenix, AZ, United States

Synopsis

Keywords: Atherosclerosis, White Matter, Atherosclerosis, Alzheimer's disease

Motivation: To understand the effect of extracranial carotid artery disease on white matter lesion (WML) accumulation.

Goal(s): Analyze WML burden on specific cerebrovascular territories.

Approach: An automated neural network-trained software was used for WML quantification in participants with and without vascular disease.

Results: Carotid stenosis severity is associated with increased WMLs in supplied cerebral territories, but not in the posterior circulation, which has alternative blood supply. Age is associated with increased WML in all cerebrovascular territories. No other vascular risk factors had a significant association.

Impact: Understanding vascular factors that exacerbate white matter lesion (WML) burden is highly relevant for treating and mitigating neurodegeneration This work describes the impact of large vessel disease on WM degeneration in contrast to previous work focused on small vessel disease.

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