Abstract #1512

The effects of aerobic fitness and BMI on brain volumes and white matter hyperintensities in coronary artery disease

Zacharie Potvin-Jutras^1,2,3, Stéfanie A. Tremblay^1,2,3, Safa Sanami^1,2,3, Ali Rezaei^1,2,3, Dalia Sabra^1,2,4, Brittany Intzandt^5,6, Lindsay N. Wright^1,2,3, Christine Gagnon², Amélie Mainville-Berthiaume⁷, Olivier Parent^8,9, Mahsa Dadar¹⁰, Josep Iglesies-Grau^2,11, Christopher J. Steele^3,7,12, Mathieu Gayda^2,11, Anil Nigam^2,11, Louis Bherer^2,11,13, and Claudine J. Gauthier^1,2,3

¹Physics Department, Concordia University, Montreal, QC, Canada, ²Centre Epic and Research Center, Montreal Heart Institute, Montreal, QC, Canada, ³School of Health, Concordia University, Montreal, QC, Canada, ⁴Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada, ⁵BrainLab, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁶Dr Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada, ⁷Department of Psychology, Concordia University, Montreal, QC, Canada, ⁸Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada, ⁹Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada, ¹⁰Department of Psychiatry, McGill University, Montreal, QC, Canada, ¹¹Department of Medicine, Université de Montreal, Montreal, QC, Canada, ¹²Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ¹³Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada

Synopsis

Keywords: Aging, Brain, Brain Volumes

Motivation: The effects of cardiorespiratory fitness and body mass index (BMI) on brain health in individuals with coronary artery disease (CAD) remains poorly understood.

Goal(s): Therefore, the objective of this study was to evaluate the effects of cardiorespiratory fitness and BMI on white matter hyperintensities, gray matter and white matter volumes in patients with CAD.

Approach: Brain volumes were measured through voxel-based morphometry and white matter hyperintensities were segmented using a validated automated classifier.

Results: Overall, cardiorespiratory fitness in patients with CAD was positively associated with gray matter volumes, while higher BMI was linked with lower gray and white matter volumes.

Impact: These findings support the importance of exercise and weight management in individuals with coronary artery disease to maintain brain health, especially in the middle cerebral arterial territory.

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