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Abstract #1571

Correlation of cognitive reserve, neurovascular coupling and cognitive function in patients with mild cognitive impairment

wenxia yang1, liang zhou1, kai Ai2, and jing zhang1
1The Second Hospital of Lanzhou University, gansu, China, 2Department of Clinical and Technical Support, Philips Healthcare, xi’an, China

Synopsis

Keywords: fMRI Analysis, Alzheimer's Disease, Mild cognitive impairment

Motivation: Cognitive reserve (CR), which can preserve cognitive function despite underlying neuropathology, explains at least some variability in cognitive performance.

Goal(s): To explore the neurovascular coupling mechanisms underlying the impact of CR on cognitive function in patients with mild MCI using ASL and rs-fMRI imaging methods.

Approach: To clarify the relationship among CR, neurovascular coupling, and cognitive performance,with correlation analysis and mediating analysis.

Results: MCI patients showed significantly lower CRIq scores, with positive correlations between MoCA, AVLT scores, and CRIq.In the MCI group, the left inferior frontal gyrus CBF/ALFF ratio was negatively correlated with CRIq, MoCA, and AVLT scores.

Impact: Individuals with higher CR demonstrate better cognitive function levels. Differential neurovascular coupling in specific brain regions between HC and MCI groups suggests a potential neural mechanism by which CR influences cognitive function.

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