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Abstract #1577

Reduced relative harmonic power of diastolic cardiovascular impulses in Alzheimer’s disease

Janne Kananen1,2, Anssi Koivula1, Vilma Perkiömäki1, Vesa Korhonen1,3, Matti Järvelä1, Johanna Kruger4, and Vesa Kiviniemi1
1University of Oulu, Oulu, Finland, 2Clinical neuroscience, Oulu university hospital, Oulu, Finland, 3Oulu university hospital, Oulu, Finland, 4Neurology, Oulu university hospital, Oulu, Finland

Synopsis

Keywords: fMRI Analysis, fMRI Analysis, fast fMRI, brain, physiological pulsations

Motivation: Alzheimer’s disease (AD) links to altered cerebrovascular brain impulse properties. Understanding these changes provides insights into AD’s impact on brain physiology.

Goal(s): This study aims to develop a frequency domain relative harmonic power (MREGRHP) method to analyze the variability of diastolic effects such as aortic notch on brain pulsations unaffected by MR signal intensity or impulse amplitude itself.

Approach: We optimized detection of cardiac waveforms using fast fMRI to boost cerebrovascular signal-to-noise ratio.

Results: MREGRHP showed reduced harmonic power in frontoparietal areas of AD patients, suggesting altered diastolic impulse patterns and increased propagation speed in brain regions usually affected by AD.

Impact: This study introduces new method, a frequency-based approach to assess cardiovascular brain impulses in Alzheimer’s disease (AD) patients. Findings reveal altered impulse patterns in regions usually affected by AD, offering potential biomarkers for understanding AD’s impact on brain hydrodynamics.

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Keywords