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Abstract #1578

Multi-echo ICA improves the sensitivity of BOLD fMRI blood flow delay estimates in subacute stroke

Rebecca G. Clements1,2, Miguel Montero3, Sebastian Urday3, Jordan Grafman4,5,6, Richard L. Harvey4,6, Molly G. Bright1,2, and Carson Ingo2,3
1Biomedical Engineering, Northwestern University, Evanston, IL, United States, 2Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 3Neurology, Northwestern University, Chicago, IL, United States, 4Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL, United States, 5Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, United States, 6Shirley Ryan Abilitylab, Chicago, IL, United States

Synopsis

Keywords: fMRI Analysis, fMRI Analysis, Denoising, multi-echo fMRI, blood flow

Motivation: Relative BOLD delays can non-invasively assess stroke-related cerebral blood flow changes. However, head motion affects data quality and limits clinical translation.

Goal(s): Evaluate whether multi-echo ICA (ME-ICA), a technique for mitigating motion effects, makes BOLD delays more sensitive to subacute stroke.

Approach: 13 participants with first-time subacute stroke, with and without clinical deficits, underwent fMRI scans. Delay laterality to lesions relative to contralesional control regions was calculated using data with ME-ICA or standard denoising.

Results: ME-ICA did not affect laterality in the group without deficits but made delays significantly more lateralized to the lesion area in the group with deficits.

Impact: ME-ICA increases the sensitivity of BOLD delay estimates to changes in cerebral blood flow for moderately severe sub-acute stroke participants. Ultimately, this work will allow for noninvasive assessment of cerebral blood flow changes with reduced participant attrition due to motion.

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