Keywords: fMRI Analysis, fMRI Analysis, Denoising, multi-echo fMRI, blood flow
Motivation: Relative BOLD delays can non-invasively assess stroke-related cerebral blood flow changes. However, head motion affects data quality and limits clinical translation.
Goal(s): Evaluate whether multi-echo ICA (ME-ICA), a technique for mitigating motion effects, makes BOLD delays more sensitive to subacute stroke.
Approach: 13 participants with first-time subacute stroke, with and without clinical deficits, underwent fMRI scans. Delay laterality to lesions relative to contralesional control regions was calculated using data with ME-ICA or standard denoising.
Results: ME-ICA did not affect laterality in the group without deficits but made delays significantly more lateralized to the lesion area in the group with deficits.
Impact: ME-ICA increases the sensitivity of BOLD delay estimates to changes in cerebral blood flow for moderately severe sub-acute stroke participants. Ultimately, this work will allow for noninvasive assessment of cerebral blood flow changes with reduced participant attrition due to motion.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords