Abstract #1607

The effects of medication on white matter integrity in obsessive-compulsive disorder

Shuangwei Chai^1,2, Hailong Li^1,2, Jiaxin Jiang^3,4, Lingxiao Cao^1,2, Huan Zhou^1,2, Bin Li³, and Xiaoqi Huang^1,2,5

¹Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, ²Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, ³Mental Health Center, West China Hospital of Sichuan University, Sichuan Clinical Medical Research Center for Mental Disorders, Chengdu, China, ⁴Chengdu Eighth People's Hospital (Geriatric Hospital of Chengdu Medical College), Chengdu, China, ⁵The Xiamen Key Lab of Psychoradiology and Neuromodulation, West China Xiamen Hospital of Sichuan University, Xiamen, China

Synopsis

Keywords: White Matter, DWI/DTI/DKI

Motivation: Studies has shown improved clinical symptoms accompanied by normalized functional connectivity after pharmacological treatment in obsessive-compulsive disorder (OCD). However, the effect of medication on structural connectivity in OCD is still unclear.

Goal(s): To investigate white matter (WM) alterations in OCD and how it would be affected by pharmacological treatments.

Approach: We utilized novel tractography toolbox TractSeg to reconstruct 72 tracts and investigate the fractional anisotropy (FA) alterations at tract level.

Results: We observed FA reduction in tracts connecting parietal and occipital to thalamus, striatal, and frontal in OCD. Patients showed symptom improvement post-treatment, while FA in these tracts were lower compared to baseline.

Impact: Although pharmacological treatment led to symptom relief in patients with OCD, this improvement was not reflected in structural connectivity. This suggests symptom alleviation in OCD may precede detectable changes in white matter microstructure following treatment.

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