Abstract #1608

Unveiling Paramagnetic and Diamagnetic Susceptibility Mechanisms in Cuprizone-Induced Demyelination

Jingjia Chen ^1,2, Jie Chen³, Rui Hu³, Zhuangheng Liu³, Xinyue Han³, Li Feng^1,2, and Nian Wang^3,4,5

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Department of Biomedical Engineering, The University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: White Matter, Degenerative, Demyelination, Susceptibility, Cuprizone

Motivation: DECOMPOSE-QSM enables separate investigation of sub-voxel paramagnetic and diamagnetic components, revealing their roles in corpus callosum demyelination.

Goal(s): To investigate the distinct contributions of paramagnetic and diamagnetic components to the demyelination process.

Approach: Multi-echo gradient echo images of five B6 control and five Cuprizone-treated mice were acquired at 9.4T. QSM images were calculated for the nonlinear DECOMPOSE-QSM signal model to generate paramagnetic (PCS) and diamagnetic (DCS) maps, followed by statistical analysis.

Results: The smaller increase in PCS compared to the decrease in DCS indicates that DCS is the primary contributor to the demyelination process.

Impact: Our findings reveal that cuprizone-induced demyelination involves diamagnetic degradation and paramagnetic deposition, underscoring the roles of PCS and DCS in guiding treatment strategies and furthering demyelination research.

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