Abstract #1609

Feature Extraction of White Matter Structures Using Quantitative Parameter Mapping: Comparison of Relaxometry, Susceptibility, and Diffusion

Emi Sato¹, Yuki Kanazawa², Masafumi Harada², Yo Taniguchi³, Masahiro Takizawa³, and Akihiro Haga²

¹Faculty of Medicine, Tokushima University, Tokushima, Japan, ²Tokushima University, Tokushima, Japan, ³FUJIFILM Corporation, Tokyo, Japan

Synopsis

Keywords: White Matter, Brain

Motivation: To confirm how many features are required to optimize the quantitative evaluation of myelin content.

Goal(s): To evaluate the relationship between relaxation rate, susceptibility, and diffusion parameters for WM regions.

Approach: Using R₁, R₂, R₁·R₂^*, and QSM derived from QPM-MRI and FA, MK, AK, and RK of diffusion kurtosis-MRI, each measured value in MNI WM region and JHU WM region was compared.

Results: There was a significant difference between each region in R₂^*, χ, FA, MK, AK, and RK values (P<0.0001). There was no significant difference in R₁, R₂^* and R₁ values. Each parameter has different characteristics in each region.

Impact: Relaxation rate, susceptibility, and diffusion parameters have different characteristics for each WM region.

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