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Abstract #1610

High-Resolution Multi-Contrast Template Construction of the Cervical Spinal Cord Using Anatomical and Diffusion MRI at 80 µm

Ibrahim S. Hattan1,2,3, Gary Cowin2,3, and Nyoman Kurniawan2,3
1Ministry of Health (MOH) and Ministry of Education (MOE), Jazan, Saudi Arabia, 2Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia, 3Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia

Synopsis

Keywords: Spinal Cord, Spinal Cord, multi-contrast Template

Motivation: The current spinal cord templates contain only anatomical MRI contrasts and have relatively low resolution, such that fine morphology specific to each level appeared unclear.

Goal(s): This study aims to construct a multi-contrast cervical spinal cord ex vivo template at 80 µm isotropic resolution of using anatomical and diffusion MRI data.

Approach: The multi-contrast template was constructed using an optimised registration protocol using T1, b0, and FA images acquired at 9.4 T.

Results: The new template displayed high anatomical delineation across the imaging contrasts, facilitating high-quality segmentation of cervical spinal cord grey and white matter structures.

Impact: This high-resolution multi-contrast template can potentially improve anatomical and microstructural analysis disease-related changes. For example, besides measuring atrophies, clinicians could use the template to pin-point subtle changes in the GM motoneuron pool due to degeneration or injuries.

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