Keywords: Spinal Cord, Spinal Cord, multi-contrast Template
Motivation: The current spinal cord templates contain only anatomical MRI contrasts and have relatively low resolution, such that fine morphology specific to each level appeared unclear.
Goal(s): This study aims to construct a multi-contrast cervical spinal cord ex vivo template at 80 µm isotropic resolution of using anatomical and diffusion MRI data.
Approach: The multi-contrast template was constructed using an optimised registration protocol using T1, b0, and FA images acquired at 9.4 T.
Results: The new template displayed high anatomical delineation across the imaging contrasts, facilitating high-quality segmentation of cervical spinal cord grey and white matter structures.
Impact: This high-resolution multi-contrast template can potentially improve anatomical and microstructural analysis disease-related changes. For example, besides measuring atrophies, clinicians could use the template to pin-point subtle changes in the GM motoneuron pool due to degeneration or injuries.
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