Abstract #1615

Automatic morphometry of spinal cord injury lesions

Jan Valošek^1,2,3,4, Dario Pfyffer^5,6, Naga Enamundram Karthik^1,2, Lynn Farner⁵, Simon Schading-Sassenhausen⁵, Patrick Freund^5,7, and Julien Cohen-Adad^1,2,8,9

¹NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Mila - Quebec AI Institute, Montreal, QC, Canada, ³Department of Neurosurgery, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic, ⁴Department of Neurology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic, ⁵Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland, ⁶Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States, ⁷Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁸Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, ⁹Centre de Recherche du CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada

Synopsis

Keywords: Spinal Cord, Spinal Cord, Spinal Cord Injury, Morphometry, Analysis Methods

Motivation: Manual measures of spinal lesion morphometry from MRI scans correlate with neurological prognosis in spinal cord injury (SCI) patients but are prone to intra- and inter-rater variability.

Goal(s): Develop a software solution that automates the measurements of lesion morphometry.

Approach: We developed a deep learning model that segments the spinal cord and intramedullary lesions, and that computes lesion length and width on the midsagittal slice. This method was compared against manual measurements in an SCI cohort.

Results: The automatic approach showed good agreement with manual measurements. The method is open-source and will be released as part of the Spinal Cord Toolbox (v6.5+).

Impact: Automatic computation of lesion morphometry can replace manual measurements, thus facilitating large multi-center studies in spinal cord injury patients by reducing intra- and inter-expert variability and saving time.

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