Abstract #1616

High-resolution and High-fidelity DTI of Cervical Cord using 3D Reduced-FOV Multiplexed Sensitivity Encoding (3D-rFOV-MUSE)

Chenglang Yuan¹, Shihui Chen^1,2, Liyuan Liang^1,2, Xiaorui Xu³, Hailin Xiong¹, Tianbaige Liu¹, Yi Li¹, Nan-Kuei Chen⁴, and Hing-Chiu Chang^1,2

¹Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China, ²Multi-Scale Medical Robotics Center, Hong Kong, China, ³Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, ⁴Department of Biomedical Engineering, University of Arizona, Arizona, Tucson, AZ, United States

Synopsis

Keywords: Spinal Cord, Spinal Cord, 3D-DWI, reduced-FOV, MUSE, multi-shot

Motivation: Diffusion tensor imaging (DTI) of cervical spinal cord (csc-DTI) based on 2D-ss-EPI often encounters several challenges, such as low attainable spatial resolution, severe geometric distortion, and Nyquist ghost.

Goal(s): To develop a 3D high-spatial-resolution and high-fidelity csc-DTI technique for addressing the current challenges existing in 2D csc-DTI.

Approach: A 3D-rFOV-MUSE technique was developed by combining 3D-MUSE with two reduced-FOV techniques, for acquiring 3D csc-DTI data with a single sagittal thin slab.

Results: Compared with routine 2D technique, our technique can mitigate through-plane partial volume effects and facilitate multi-planar data reformation for csc-DTI, with effective reductions of distortions and substantial improvements in SNR.

Impact: The proposed 3D-rFOV-MUSE technique can produce high-fidelity csc-DTI at 1.0 mm-isotropic resolution, which can precisely assess the microstructural integrity of the cervical spinal cord. This may provide further pathophysiological insights to aid differential diagnosis for different cervical spinal cord diseases.

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