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Abstract #1660

Vendor-neutral MP2RAGE with Pulseq in VENUS: Three vendors and five scanners

Agah Karakuzu1, Akifumi Hagiwara2, Wataru Uchida2, Koji Kamagata2, Shohei Fujita3, Bilal Tasdelen4, Jon-Fredrik Nielsen5, Shigeki Aoki2, and Nikola Stikov1
1NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada, 2Department of Radiology, Juntendo University, Tokyo, Japan, 3Athinoula. A.Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, 4Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 5University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Vendor-neutral Acquisition

Motivation: MP2RAGE began as an open-source method, gaining popularity for its superior gray/white-matter T1w contrast and rapid T1 mapping. However, its adoption has been hindered by limited multi-vendor implementation.

Goal(s): To develop a vendor-neutral MP2RAGE framework that enhances accessibility and reproducibility across five 3T scanners from Canon, GE, and Siemens.

Approach: Implemented an open-source MP2RAGE using Pulseq for acquisition, BART for reconstruction, and qMRLab for processing, evaluated on reference phantoms and a healthy subject.

Results: The vendor-neutral implementation demonstrated consistent contrast characteristics across scanners. T1 measurements in phantoms exhibited acceptable agreement with the ground-truth, although they showed slightly greater deviations compared to vendor-native implementations.

Impact: Successfully deployed to five 3T scanners from three vendors, Pulseq-MP2RAGE standardizes the entire workflow using VENUS. This approach paves a rigorous path to elevate quantitative MRI to a metrological standard, unlocking the estimation of measurement uncertainties free from vendor-native discrepancies.

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Keywords