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Abstract #1661

Multi-vendor reproducibility of joint T1-T2 transient-state relaxometry using platform-specific implementations at 3T

Marta Lancione1, Matteo Cencini2,3, Domenico Aquino4, Cristina Baldoli5, Maurizio Elia6, Francesco Ghielmetti4, Domenico Montanaro1, Ilaria Neri5, Anna Nigri4, Rosa Pasquariello1, Salvatore Pettinato6, Salvatore Romano6, Alessandro Sbrizzi7, Paola Scifo5, Oscar Van der Heide7, Edwin Versteeg7, Laura Biagi1, and Michela Tosetti1
1IRCCS Stella Maris Foundation, Pisa, Italy, 2National Institute for Nuclear Physics (INFN), Pisa Division, Pisa, Italy, 3IMAGO7 Foundation, Pisa, Italy, 4IRCCS Carlo Besta Neurological Institute, Milan, Italy, 5IRCCS San Raffaele Hospital, Milan, Italy, 6IRCCS Oasi Maria SS, Troina, Italy, 7University Medical Center, Utrecht, Netherlands

Synopsis

Keywords: MR Fingerprinting, Quantitative Imaging, reproducibility; multi-center; multi-vendor

Motivation: Transient-state relaxometry (TSR) provides fast estimation of T1 and T2 but the variability of implementations across different vendors may compromise multi-center studies.

Goal(s): To assess accuracy, repeatability and inter-vendor reproducibility of TSR T1 and T2 maps.

Approach: A phantom and five volunteers were scanned at four 3T MR systems from three manufacturers. We computed coefficients-of-variation to estimate voxelwise variability and general linear model analysis to measure biases associated with sites.

Results: We obtained excellent accuracy and repeatability and generally good inter-site reproducibility among the different implementations. T1 and T2 differences may be attributable to MT and B1 effects, respectively.

Impact: Transient-state relaxometry represents a broadly applicable method for quantitative imaging. The assessment of inter-site reproducibility provides a preliminary indication of its sensitivity in detecting pathologies in a multi-center study.

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Keywords