Keywords: Quantitative Imaging, Perfusion
Motivation: To validate DSC-MRI reliability in MS for detecting microvascular changes, enhancing disease monitoring and patient management.
Goal(s): The purpose of this study is to assess the test-retest reliability of perfusion MRI using dynamic susceptibility contrast (DSC) in multiple sclerosis (MS) patients and healthy controls
Approach: By evaluating cerebral blood volume (CBV) and cerebral blood flow (CBF) metrics in both lesion areas and normal-appearing white matter (NAWM), we assess the repeatability of total and microvascular perfusion measures
Results: Results show moderate to high repeatability in perfusion metrics within lesion areas, with increased variability in NAWM, particularly in microvascular CBV and CBF
Impact: These differences suggest microvascular abnormalities in NAWM, potentially contrasting with the stable metrics seen in lesion areas or healthy controls.These findings underscore the reliability of DSC-based perfusion MRI and its utility in tracking hemodynamic changes in MS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords