Abstract #1672

Combined Quantitative Fat and Stiffness Phantom for Simultaneous CSE-MRI and MRE Quality Assurance of Steatotic Liver Disease

David R Rutkowski¹, Raphael do Vale Souza², José Guerrero-González¹, Jeff Kammerman¹, Robert Moskwa¹, Matthew W Urban³, Phillip J Rossman³, Kay Pepin^3,4, Jeremy Heilman^3,4, Diego Hernando^1,2,5, Scott B Reeder^1,2,5,6,7,8, and Jean H Brittain¹

¹Calimetrix, LLC, Madison, WI, United States, ²Radiology, University of Wisconsin, Madison, WI, United States, ³Mayo Clinic, Rochester, MN, United States, ⁴Resoundant, Rochester, MN, United States, ⁵Medical Physics, University of Wisconsin, Madison, WI, United States, ⁶Biomedical Enginering, University of Wisconsin, Madison, WI, United States, ⁷Medicine, University of Wisconsin, Madison, WI, United States, ⁸Emergency Medicine, University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Phantoms, Phantoms, MRE

Motivation: A quantitative fat/stiffness phantom would facilitate quality assurance of chemical shift encoded (CSE) MRI and MR elastography (MRE) data.

Goal(s): Develop a quantitative fat/stiffness phantom that simultaneously mimics clinically-relevant levels of proton density fat fraction (PDFF) and stiffness.

Approach: Formulated PDFF-stiffness gels were poured into a housing with stackable cylindrical compartments and an integrated passive MRE driver. PDFF and stiffness were measured in each compartment and stiffness was externally validated with mechanical testing.

Results: A phantom was fabricated with target PDFF/stiffness values of 0%/1.5kPa, 10%/3kPa, and 20%/4kPa. MRE stiffness values correlated well with external mechanical testing (r² = 0.95).

Impact: A quantitative three-compartment fat/stiffness phantom was developed and optimized to address the need for standardized quality assurance of quantitative MRI biomarkers of steatotic liver disease.

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