Abstract #1683

Evaluating Breast Lesions with Ultrafast DCE-MRI: The Impact of Temporal Resolution on Pharmacokinetics

Tianwen Xie^1,2, Yan Huang^1,2, Caixia Fu³, Robert Grimm⁴, Marcel Dominik Nickel⁴, Qin Xiao^1,2, Ruimin Li^1,2, Weijun Peng^1,2, and Yajia Gu^1,2

¹Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, ²Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, ³MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁴MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany

Synopsis

Keywords: Quantitative Imaging, DSC & DCE Perfusion, Breast

Motivation: Ultrafast DCE (UF-DCE) MRI can improve the detection of breast cancer. The influence of temporal resolution in determining pharmacokinetic parameters using UF-DCE technique remains unclear.

Goal(s): This study aimed to evaluate the impact of temporal resolution on pharmacokinetic parameters and the performance in diagnosing breast cancer.

Approach: The UF-DCE data with a native temporal resolution of 4.5 seconds were downsampled at various temporal resolutions ranging from 9.0 to 58.5 seconds.

Results: As temporal resolution decreased from 4.5 seconds, K^trans and k_ep values increased, while v_e values decreased.

Impact: This study advances breast cancer diagnosis by validating the impact of temporal resolution on pharmacokinetic parameters, promoting broader adaptations to enhance accuracy in quantitative pharmacokinetic assessment for cancer diagnosis and prognosis across institutions and imaging modalities.

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