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Abstract #1695

Measuring cerebrovascular reactivity: a comparison of Gradient-Echo and Spin-Echo BOLD with Arterial Spin Labelling

Sara Pomante1,2, Fabrizio Fasano3,4, Davide Di Censo1,2, Stefano Censi1,2, Francesca Graziano1,2, Manuela Carriero1,2, Ekaterina Bliakharskaia1,2, Alessandra Stella Caporale1,2, Emma Biondetti1,2, Michael Germuska5, Richard Geoffrey Wise1,2, and Antonio Maria Chiarelli1,2
1Department of Neurosciences, Imaging and Clinical Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy, 2Institute for Advanced Biomedical Technologies, University "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy, 3Siemens Healthcare, Camberley, United Kingdom, 4Siemens Healthineers AG, Forchheim, Germany, 5Department of Radiology, University of California Davis Medical Center, Sacramento, CA, United States

Synopsis

Keywords: Quantitative Imaging, Vascular, cerebrovascular reactivity, Gradient Echo BOLD, Spin Echo BOLD, ASL

Motivation: Gradient-echo (GE) BOLD-fMRI has been used with vasodilation to measure the cerebrovascular reactivity (CVR). However, the GE-BOLD signal is weighted by cerebral blood volume (CBV) in large veins. Spin-Echo (SE) BOLD fMRI is less sensitive to large veins and may deliver estimates closer to the physiological CVR.

Goal(s): To compare GE-BOLD, SE-BOLD, and CBF based CVR measurements across subjects and across space.

Approach: Concurrent GE/SE BOLD-ASL acquisitions were performed during breath-holding (BH). We computed the CVR maps for the three signals.

Results: The grey matter (GM) SE-BOLD CVR correlated more highly than GE-BOLD CVR with the ASL-derived GM CBF-CVR, across subjects and space.

Impact: SE BOLD-fMRI may deliver a marker of CVR that resembles the physiological (CBF) CVR more closely than CVR based on GE BOLD, with the advantage of high signal-to-noise ratio compared to ASL.

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Keywords