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Abstract #1696

Rapid Mapping of Myelin Fraction Using Interleaved Multi-Echo UTE Acquisitions

Jiyo S Athertya1, James Lo1,2, Jiaji Wang1, Soo Hyun Shin1, Arya Suprana1,2, Eric Y Chang1,3, Yajun Ma1, and Jiang Du1,2,3
1Department of Radiology, UCSD, San Diego, CA, United States, 2Department of Bioengineering, UCSD, San Diego, CA, United States, 3Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: Quantitative Imaging, Signal Modeling, UTE imaging, Myelin

Motivation: Myelin plays a critical role in brain function. It is important to quantify myelin in human brain.

Goal(s): To develop a fast myelin fraction estimation technique that incorporates two interleaved multi-echo UTE acquisitions.

Approach: An interleaved 3D UTE multi-echo acquisition scheme was employed to capture signals from the short T2 myelin and long T2 water components. Myelin and water fractions were estimated using a bi-component fitting of UTE signal decay.

Results: Bicomponent T2* analysis of UTE signals detects T2*s and fractions of the ultrashort T2 component (myelin) and the long T2 component (intra-extra cellular water).

Impact: The interleaved multi-echo UTE acquisition scheme allows rapid estimation of myelin fraction, which may be a useful biomarker to assess demyelination in various neurodegenerative conditions.

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Keywords