Keywords: Quantitative Imaging, Quantitative Imaging, multi-parametric quantitative MRI (MP-qMRI), phase-cycled balanced steady-state free precession (pc- bSSFP)
Motivation: Magnetic resonance relaxation anisotropy in tissue has been reported previously for both T1 and T2, with implications to assess the integrity of tissue microstructure.
Goal(s): To evaluate the dependency on brain tissue anisotropy and white matter fiber orientation of relaxometry metrics (T1, T2) and asymmetry index (AI), derived from phase-cycled bSSFP (pc-bSSFP), in a large cohort of healthy subjects.
Approach: 80 healthy subjects were scanned at 3T using pc-bSSFP and diffusion tensor imaging. T1 and T2 were quantified using MIRACLE - an SSFP configuration-based approach.
Results: All metrics (T1, T2, AI) showed a distinct sensitivity to white matter fiber orientation and fractional anisotropy.
Impact: Relaxation parameters and frequency profile asymmetries derived from pc-bSSFP demonstrated a distinct sensitivity to brain tissue microstructure, with a dependency on white matter fiber orientation and fractional anisotropy.
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