Meeting Banner
Abstract #1697

Dependency on Tissue Anisotropy and White Matter Fiber Orientation of Phase-Cycled bSSFP Relaxometry at 3 Tesla

Hamzeh Tesh1, Florian Birk1,2, Svenja Klinkowski1,3, Svenja Brodt1, Klaus Scheffler1,2, and Rahel Heule1,2,4
1High-Field Magnetic Resonance,, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Department of Biomedical Magnetic Resonance, University Hospital Tuebingen, Tuebingen, Germany, 3Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Tuebingen, Germany, 4Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, multi-parametric quantitative MRI (MP-qMRI), phase-cycled balanced steady-state free precession (pc- bSSFP)

Motivation: Magnetic resonance relaxation anisotropy in tissue has been reported previously for both T1 and T2, with implications to assess the integrity of tissue microstructure.

Goal(s): To evaluate the dependency on brain tissue anisotropy and white matter fiber orientation of relaxometry metrics (T1, T2) and asymmetry index (AI), derived from phase-cycled bSSFP (pc-bSSFP), in a large cohort of healthy subjects.

Approach: 80 healthy subjects were scanned at 3T using pc-bSSFP and diffusion tensor imaging. T1 and T2 were quantified using MIRACLE - an SSFP configuration-based approach.

Results: All metrics (T1, T2, AI) showed a distinct sensitivity to white matter fiber orientation and fractional anisotropy.

Impact: Relaxation parameters and frequency profile asymmetries derived from pc-bSSFP demonstrated a distinct sensitivity to brain tissue microstructure, with a dependency on white matter fiber orientation and fractional anisotropy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords