Abstract #1698

Correlation between clot RBC content and susceptibility measurements on QSM: an investigation using ex vivo clot analogs

Hideki Ishimaru¹, Yoichi Morofuji², Minoru Morikawa³, Ayano Ishiyama¹, Chika Somagawa¹, Tomoki Nakano¹, Yutaro Tasaki³, Syuhei Miyazaki¹, and Ryo Toya¹

¹Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Neurosurgery, Nagasaki University Hospital, Nagasaki, Japan, ³Radiology, Nagasaki University Hospital, Nagasaki, Japan

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mapping

Motivation: No mathematical model has yet been established to predict the clot RBC content using MRI. Because RBC are paramagnetic, it may be possible to predict the RBC content using QSM.

Goal(s): Do susceptibility values on QSM reflect clot RBC content?

Approach: Porcine clot analogs with various RBC contents were made and examined ex vivo using 3T MRI. Each susceptibility value was measured on the generated QSM.

Results: The susceptibility value of clots measured on QSM had a strong positive linear correlation with clot RBC content.

Impact: A strong positive linear correlation was observed between the susceptibility values of clots measured on QSM and RBC content. By measuring the susceptibility value of clots on QSM, it is possible to estimate the RBC content in the clots.

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