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Abstract #1699

MEGA-PRESS Study of Neurotransmitter Changes and Lateralization in the DLPFC in rTMS Treatment for First-Episode Adolescent Depression

Laiyang Ma1, Jing Zhang1,2, and Yuhui Xiong3
1Lanzhou University Second Hospital, LanZhou, China, 2Department of Magnetic Resonance, Lanzhou University Second Hospital, LanZhou, China, 3GE Healthcare MR Research, BeiJing, China

Synopsis

Keywords: Quantitative Imaging, MR Value

Motivation: The impact of TMS on neurotransmitter levels in the DLPFC of depression patients remains uncertain.

Goal(s): The aim of this study is to investigate the effects of TMS on neurotransmitter changes and lateralization in the DLPFC of adolescent patients with first-episode depression

Approach: MRS Data were acquired from the left and right DLPFC using the MEGA-PRESS sequence

Results: We found that compared with HCs, the concentrations of GABA and Glx on the left and right sides of the First-episode adolescent depression are different. The concentration of left side changed after rTMS. There was no significant change on the right side.

Impact: 3-T 1H-MRS can be used to measure the changes of GABA and Glx concentrations in patients with depression before and after rTMS treatment, which provides a theoretical basis for exploring the occurrence and treatment mechanism of depression.

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