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Abstract #1700

Fast and Reproducible 3D T1ρ Mapping Using Unpaired Phase Cycling and Optimal Sampling of Spin-Lock Times

Sandeep Panwar Jogi1, Qi Peng2, Ramin Jafari3, Ricardo Otazo1,4, and Can Wu1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States, 3MR Clinical Science, Philips Healthcare, Cambridge, MA, United States, 4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, T1rho, T1ρ, Reproducibility, Spin-lock times, Phase cycling

Motivation: Fast and reproducible T1ρ imaging would be beneficial in longitudinal studies for evaluating treatment responses in radiotherapy.

Goal(s): To enhance reproducibility and accelerate MAPSS T1ρ imaging using unpaired phase cycling combined with reproducibility-guided optimal sampling (ROS) of spin-lock times (TSLs).

Approach: 3D T1ρ imaging was performed with eight pairs of TSLs on a phantom over ten different days. The coefficient of variation and changes in T1ρ values were evaluated for paired and unpaired MAPSS.

Results: The ROS scheme significantly improved the performance of the unpaired MAPSS sequence while reducing scan time by 75% compared to paired MAPSS for T1ρ imaging.

Impact: 3D T1ρ imaging, utilizing optimal spin-lock time (TSL) sampling in combination with unpaired MAPSS, enables rapid and highly reproducible T1ρ measurements. This advancement facilitates longitudinal studies, such as assessing treatment response in radiotherapy.

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Keywords