Meeting Banner
Abstract #1732

Quantification of Apparent Tissue Sodium Concentration (aTSC) in the Healthy Liver via 23Na and 1H MRI at 7T

Jana Losch1,2, Anna K Scheipers1,2, Johannes A Grimm1,2, Armin M Nagel1,3, Stephan Orzada1, Sebastian Schmitter1,4, Mark E Ladd1,2,5, and Tanja Platt1
1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 5Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Synopsis

Keywords: Liver, Multi-Contrast, 23Na MRI, X nuclei, Ultrahigh-Field MRI

Motivation: This study seeks to enhance the appeal of using quantitative 23Na MRI in clinical settings by providing essential reference data for healthy tissue.

Goal(s): The goal is to determine the mean aTSC in the healthy liver as reference for diseased livers and to identify potential methodological limitations.

Approach: In this study, we determined liver aTSC in 7 healthy volunteers using 1H images for segmentation and B1+- and B1--corrected 23Na images for quantification.

Results: The healthy liver’s aTSC was found to be (37.0 ± 11.4) mmol/l after fasting overnight, potentially impacted by nutrition, voxel model for B1- corrections, and sodium calibration setup.

Impact: This study provides essential reference data for 23Na MRI in healthy livers and also highlights the need to investigate correlations between aTSC, B1- correction, food intake, and calibration methods in healthy livers.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords