Meeting Banner
Abstract #1733

NMR and multi-omics reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection

Yan Zhao1,2, Rongzhi Cai1, Lixin Ke1, Zhiheng Li1, Enqi Wang1, and Yan Lin1
1Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China, Shantou, China, 2Central Laboratory, Clinical Research Center, Shantou Central Hospital, Shantou, Guangdong, China., Shantou, China

Synopsis

Keywords: Digestive, biomarkers

Motivation: It remains unclear whether detectable characteristic metabolome exists in ESCC tissues and biofluids for early detection.

Goal(s): We aims to identify biofluid metabolic biomarkers that reflect alterations in ESCC tissue metabolism and validate metabolic changes at various dimensions.

Approach: Multi-omics approaches including metabolomics, proteomics, and microbiomics were employed, tissue, serum, urine and saliva from 1171 cases of ESCC patients and corresponding control groups were analyzed.

Results: Metabolomic analysis revealed that amino acid metabolism are pivotal in ESCC progression. The diagnostic efficacy of serum and urine metabolite biomarkers outperformed conventional markers. Moreover, the study delved into the exploration of ESCC-related microbiome and protein features.

Impact: The combined model of biofluid metabolite biomarkers based on NMR exhibits high diagnostic accuracy and plays a crucial role in early detection of ESCC, facilitating precise screening for high-risk populations.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords