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Abstract #1736

Regional Quantification of Metabolic Liver Function Using Hyperpolarized [1-13C] Pyruvate MRI

Uffe Kjærgaard1,2, Andrea Lund2, Mohsen Redda1, Mattias Hedegaard Kristensen1, Malene Aastrup1, Nikolaj Bøgh1, Kim Sivesgaard3, Michael A. Ohliger4, Daniel B. Vigneron4, Lotte Bonde Bertelsen1, Aage Kristian Olsen Alstrup5, Esben Søvsø Szocska Hansen1, Frank Viborg Mortensen2, and Christoffer Laustsen1
1The MR-Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark, 2Department of Surgery, Aarhus University Hospital, Aarhus University, Aarhus N, Denmark, 3Department of Radiology, Aarhus University Hospital, Aarhus University, Aarhus N, Denmark, 4Department of Radiology & Biomedical Imaging, University of California, San Francisco, CA, United States, 5Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus University, Aarhus N, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Liver, Surgery, Metabolism

Motivation: To prevent post-hepatectomy liver failure (PHLF) it is essential to assess liver function in the future liver remnant prior to surgery, currently volumetric measurement is used as a surrogate for liver function.

Goal(s): We aimed to investigate if regional metabolic liver function could be assessed non-invasively.

Approach: We used hyperpolarized [1-13C] pyruvate MRI to quantify regional metabolic changes following partial portal vein ligation in pigs.

Results: Results demonstrated higher pyruvate to lactate in the future liver remnant compared to the deportalized liver (P=0.002).

Impact: Hyperpolarized MRI can quantify regional metabolic liver function and may be utilized to assess liver function preoperatively to predict patients in risk of PHLF.

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Abstract

Keywords