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Abstract #1737

MR Measurements of Tolvaptan Effect on TKV: Experience in 36 ADPKD Patients

Hreedi Dev1, Arman Sharbatdaran1, Jon D. Blumenfeld2,3, Chenglin Zhu1, Daniil Shimonov2, James M. Chevalier2, Stephanie Donohue2, Arindam RoyChoudhury4, Alan Wu5, and Martin R. Prince1,6
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Rogosin Institute, New York, NY, United States, 3Medicine, Weill Cornell Medicine, New York, NY, United States, 4Population Health Sciences, Weill Cornell Medicine, New York, NY, United States, 5Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, United States, 6Radiology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States

Synopsis

Keywords: Kidney, Treatment Response, ADPKD

Motivation: Traditional TKV measurement methods for assessing tolvaptan response in ADPKD are variable and limits accurate identification of responders. Reliable, reproducible tools are essential to identify patients likely to benefit from tolvaptan.

Goal(s): A reproducible MRI technique tracks ht-TKV growth and identifies predictive markers for tolvaptan responders.

Approach: A retrospective analysis of 36 ADPKD patients used MRI with deep-learning segmentation to measure ht-TKV growth before and during tolvaptan use and incorporated demographics, urine osmolality, and spleen volume.

Results: Tolvaptan reduced ht-TKV growth in over half the patients, with responders mostly male and having higher pre-treatment urine osmolality, thus emphasizing MRI's utility in individual assessment.

Impact: MRI-based ht-TKV measurements and serum urine osmolality can now be used to more accurately assess individual responses to tolvaptan in ADPKD. This enables radiologists and nephrologists to tailor treatments by identifying those most likely to benefit from therapy.

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