Abstract #1754

Lower body negative pressure recapitulates upright posture during supine exercise cardiac magnetic resonance imaging

Brandon Hathorn¹, Sauyeh Zamani², Ram Webb¹, Christian Grant¹, Logan Pixler¹, Neeki Ashari³, Jing Wang⁴, Vlad G Zaha⁵, and Michael D Nelson¹

¹University of Texas at Arlington, Arlington, TX, United States, ²Georgia College and State University, Milledgeville, GA, United States, ³University of California San Diego, San Diego, CA, United States, ⁴University of Utah Health, Salt Lake City, UT, United States, ⁵UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Myocardium, New Devices, Exercise Cardiac MRI; Lower Body negative Pressure; Simulated Upright Exercise; Cardiac Hemodynamics

Motivation: Supine positioning causes a hemodynamic shift towards the central circulation, minimizing changes in cardiac function during exercise cardiac MRI (cMRI).

Goal(s): Simulate upright posture during supine exercise cMRI.

Approach: Lower body negative pressure (LBNP) pants were constructed in-house and used to simulate upright posture during supine exercise cMRI.

Results: Simulating upright posture during exercise cMRI with LBNP doubles the dynamic range of stroke volume, recapitulating the cardiac hemodynamic response expected during exercise in the upright posture.

Impact: The results herein highlight the importance of performing exercise cMRI under conditions that simulate normal upright posture, and move exercise cMRI one step closer to broad clinical adoption.

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