Abstract #1758

Assessing sex and age effect on ventricular stiffness using cardiac Multifrequency MR Elastography

Johannes Castelein^1,2, Amanda Duus², Pernille Bække³, Ingolf Sack⁴, Noah Jaitner⁴, Adam Hansen⁵, Rudi Dierckx⁶, Ole de Backer³, Niels Vejlstrup³, Morten Lund², Thomas Jespersen², and Ronald Borra^1,7

¹Department of Radiology, University Medical Center Groningen, Groningen, Netherlands, ²Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ³The Heart Centre, Rigshospitalet Copenhagen, Copenhagen, Denmark, ⁴Department of Radiology, Charite – Universitätsmedizin Berlin, Berlin, Germany, ⁵Department of Radiology, Rigshospitalet Copenhagen, Copenhagen, Denmark, ⁶Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, Netherlands, ⁷2nd Department of Radiology, Medical University of Gdańsk, Gdańsk, Poland

Synopsis

Keywords: Myocardium, Elastography

Motivation: Ventricular stiffness is a critical indicator of diastolic function, but its clinical assessment remains challenging. Cardiac Multifrequency MRE (MMRE) offers a non-invasive approach to quantify ventricular stiffness.

Goal(s): To investigate diastolic ventricular stiffness variations with age and sex using cardiac MMRE.

Approach: A prospective study of 40 healthy controls underwent cardiac MMRE. Shear wave speed maps were reconstructed for left and right ventricles.

Results: An interaction effect between age and sex was observed. Females showed a significant increase in ventricular stiffness with age in both ventricles, while males did not. This study marks the first non-invasive quantification of right ventricular stiffness using MMRE.

Impact: Cardiac MMRE enables non-invasive quantification of both LV and RV stiffness. This technique unveils sex-specific age-related changes in ventricular stiffness, potentially leading to personalized cardiovascular risk stratification and treatment strategies. It opens new avenues for investigating sex-specific cardiac aging mechanisms.

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