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Abstract #1774

Deep Medullary Vein Density are associated with Paraventricular White Matter Hyperintensities and Brain Atrophy: An Automated Analysis of SWI

Surendra Maharjan1, Ludvik Alkhoury1, Xiuyuan Hugh Wang1, Liangdong Zhou1, Tracy Butler1, Yi Li1, Emily B. Tanzi1, Gloria Chia-Yi Chiang1, Mony J. de Leon1, and Lidia Glodzik1
1Brain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Blood Vessels, Blood vessels, SWI

Motivation: Periventricular white matter hyperintensities (PWMH) are associated with cerebral small vessel disease (CSVD), yet their pathophysiology remains poorly understood. Recent evidence suggests that microvascular changes, including venous abnormalities could play a significant role in PWMH and brain atrophy.

Goal(s): To investigate whether deep medullary veins (DMVs) density, as measured by Susceptibility Weighted Imaging (SWI) correlates with PWMH burden and brain atrophy.

Approach: Automatic quantification of DMVs density on SWI images.

Results: At cross-section DMVs density was significantly lower in participants with high PWMH burden. In longitudinal analyses lower DMVs density was related to lower brain volume, independently of baseline PWMH burden.

Impact: This study underscores the importance of venous health in CSVD, relating reduced DMVs density with PWMH pathology and brain volume, thus providing a potential additional biomarker for neurovascular pathology.

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