Abstract #1782

Comparison of single-band versus multi-band phase contrast MRI for the estimation of pulse transit time as a measure of neurovascular stiffness

Benjamin Keedwell¹, Aaron T. Hess¹, Thomas W. Okell¹, Iulius Dragonu², Yang Ji³, Mark Chiew^4,5, and Peter Jezzard¹

¹Wellcome Centre for Integrative Neuroimaging (WIN FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Research & Collaborations GB&I, Siemens Healthcare Ltd, Camberley, United Kingdom, ³Department of Electronic Engineering and Information Science, School of Information Science and Technology, University of Science and Technology of China, Hefei, China, ⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

Synopsis

Keywords: Blood Vessels, Velocity & Flow, Pulse Wave Velocity, Arterial Stiffness, Phase Contrast MRI, Simultaneous Multi-Slice

Motivation: Neurovascular pulse wave velocity (PWV) measurements have the potential to quantify vascular risk locally in the brain but are limited by the long acquisition time of sequential single-band scans.

Goal(s): We aim to compare the reproducibility of neurovascular pulse transit time (PTT) measurements in single-band and multi-band phase contrast MRI (PC-MRI) acquisitions.

Approach: Four subjects were scanned at 3T with repeated single-band and multi-band PC-MRI scans. The differences in repeated PTT measurements are compared across acquisition types for multiple vascular paths.

Results: The full time-efficiency improvement of multi-band acquisition was achieved with no significant difference in PTT reproducibility.

Impact: Phase contrast MRI scans for the assessment of neurovascular stiffness can be accelerated by a factor of five through a simultaneous multi-slice acquisition without a significant difference in the reproducibility of pulse transit time measurements.

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