Keywords: Blood Vessels, Blood vessels, fast imaging, ZTE, preclinical image analysis
Motivation: Brain vascular pulsations are difficult to detect in the rat brain because they occur at a much faster frequency (5 - 7 Hz) than the volume TR (0.5 - 1 Hz).
Goal(s): To detect vascular pulsations in the rat brain with EVEnt-Recurring ZTE approach.
Approach: Event-recurring resampling to 8-9 ms temporal resolution was applied to resting-state rat ZTE fMRI data measured under isoflurane anesthesia. Heartbeat timings were estimated from simultaneous ECG measurements.
Results: Pulsations and brain-wide pulse wave propagations were clearly detected during one heartbeat cycle. As ZTE sequence has a strong in-flow contribution, the pulsation was most visible in the main cerebral arteries.
Impact: EVER-ZTE enables the robust detection of brain vascular pulsations in preclinical settings, providing a unique opportunity to measure non-invasively critical physiological parameters linked to brain health at the same time with traditional fMRI measurement.
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